Hereditary bone lesions — definition?
Genetic disorders affecting bone structure or growth.
Osteogenesis imperfecta — key feature?
Fragile bones with frequent fractures.
Osteopetrosis — cause?
Defective osteoclast-mediated bone resorption.
Cherubism — inheritance?
Autosomal dominant.
Cleido-cranial dysplasia — main abnormality?
Clavicular aplasia and cranial deformities.
Hereditary vs acquired lesions — difference?
Genetic origin versus environmental or infectious causes.
Acquired bone lesions — examples?
Osteomyelitis, osteoradionecrosis, fibrous dysplasia.
Osteomyelitis — primary cause?
Bacterial infection.
Sequestrum — what?
Dead bone separated during osteomyelitis.
Involucrum — what?
Reactive new bone around sequestrum.
Osteoradionecrosis — trigger?
Radiation therapy.
Central giant cell granuloma — cell type?
Multinucleated giant cells in fibrous tissue.
Neoplastic bone disease — common benign?
Osteoma.
Osteosarcoma — radiographic feature?
Sunburst periosteal reaction.
Chondrosarcoma — origin?
Malignant cartilage-producing cells.
Ewing sarcoma — typical age?
Children and adolescents.
Giant cell tumor — location?
Epiphysis of long bones.
Inflammatory bone condition — hallmark?
Bone destruction with sequestrum formation.
Osteomyelitis types — examples?
Acute suppurative, chronic, proliferative periostitis.
Osteoradionecrosis — diagnosis?
Exposed necrotic bone >3 months post-radiation.
Bone necrosis — cause?
Impaired blood supply.
Dystrophic bone disease — example?
Paget’s disease.
Hormonal bone disorder — example?
Hyperparathyroidism.
Nutritional bone disease — cause?
Vitamin D deficiency (rickets, osteomalacia).
Testez vos connaissances avec un QCM de 12 questions sur Bone Pathology: Hereditary to Inflammatory.
1. What are hereditary bone lesions?
2. Which bacteria are commonly responsible for causing osteomyelitis?
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