Flashcards : Flavivirus Biology and Disease Mechanisms — 21 cartes

Toutes les cartes

1Question

Flaviviruses — classification?

Réponse

Positive-sense ssRNA viruses in Flaviviridae.

2Question

Flavivirus genome — type?

Réponse

Non-segmented, single polyprotein RNA.

3Question

Flavivirus replication — location?

Réponse

Cytoplasm within ER-derived vesicles.

4Question

DENV vectors — primary?

Réponse

Aedes aegypti and albopictus mosquitoes.

5Question

Zika manifestations — congenital?

Réponse

Microcephaly and congenital Zika syndrome.

6Question

Flavivirus entry — mechanism?

Réponse

Receptor-mediated endocytosis and fusion.

7Question

Genome translation — site?

Réponse

At the ER as a polyprotein.

8Question

Viral maturation — process?

Réponse

prM cleavage in Golgi.

9Question

Dengue severity — key factor?

Réponse

Prior infection and immune enhancement.

10Question

Zika — neurological complication?

Réponse

Guillain-Barré syndrome.

11Question

Picornaviruses — classification?

Réponse

(+): ssRNA, non-enveloped, T=3 capsid.

12Question

Poliovirus vaccine — type?

Réponse

Inactivated (Salk) and live attenuated (Sabin).

13Question

Salk vaccine — characteristic?

Réponse

Inactivated, no reversion risk.

14Question

Sabin vaccine — advantage?

Réponse

Oral, induces intestinal immunity.

15Question

Vaccine reversion — risk?

Réponse

Sabin vaccine can mutate back to neurovirulent form.

16Question

cVDPV — meaning?

Réponse

Vaccine-derived poliovirus from mutated Sabin strains.

17Question

ADE — stands for?

Réponse

Antibody-dependent enhancement.

18Question

ADE — occurs when?

Réponse

At intermediate cross-reactive antibody titers.

19Question

Dengue — severe form?

Réponse

DHF and DSS with vascular leakage.

20Question

NS1 — role in pathogenesis?

Réponse

Induces endothelial dysfunction and leakage.

21Question

Zika — transmission?

Réponse

Mosquito-borne and vertical (mother to fetus).

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1. What does Flavivirus classification refer to?

2. Which mosquito species are primarily responsible for transmitting flaviviruses such as Dengue and Zika?

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