Glomerulonephritis types — main categories?
Membranous, MPGN, IgA nephropathy, primary and secondary.
Membranous GN — characteristic feature?
Electron-dense basement membrane thickening with spikes.
MPGN Types I & II — deposit location?
Type I: subendothelial; Type II: intramembranous dense deposits.
IgA nephropathy — deposits?
Mesangial IgA deposits with complement activation.
Primary vs secondary GN — difference?
Primary: intrinsic; secondary: systemic disease causes.
Basement membrane spikes — seen in?
Membranous glomerulonephritis.
t(10;18) translocation — associated lymphoma?
Follicular lymphoma, causes Bcl-2 overexpression.
Sezary syndrome cells — immunophenotype?
CD2+, CD3+, CD4+, CD7-.
HER2/neu — role in breast cancer?
Prognostic marker and therapeutic target.
HPV-12 — associated lesion?
Verruca (wart).
t(2;5)(p23;q35) — lymphoma?
Anaplastic large cell lymphoma (ALK fusion).
Mantle cell lymphoma — markers?
CD20+, CD5+, cyclin D1+; t(11;14).
ALCL — genetic feature?
t(2;5)(p23;q35), ALK fusion gene.
Reactive lymph node features?
Hyperplastic germinal centers, granulomas.
Membranous GN — immune deposits?
Subepithelial immune complexes.
MPGN — complement involvement?
Yes, especially in Type II (dense deposit disease).
IgA nephropathy — clinical trigger?
Mucosal infections causing episodic hematuria.
Tumor staging — purpose?
Guide prognosis and treatment based on extent.
pT3b N1 — indicates?
Deep invasion and regional lymph node metastasis.
Histological grading in breast carcinoma?
G1: well-differentiated; G2: moderate; G3: poor.
Testez vos connaissances avec un QCM de 10 questions sur Pathology of Tumors and Glomerulonephritis.
1. What is membranous glomerulonephritis primarily characterized by?
2. Which genetic translocation is associated with bcl-2 overexpression in follicular lymphoma?
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