Wound — definition?
A break in tissue integrity needing repair.
Wound healing — process?
Physiological repair restoring tissue structure and function.
Scar formation — mechanism?
Fibrous tissue replaces damaged tissue for stability.
Regeneration — goal?
Restore original tissue architecture and function.
Phases of healing?
Inflammatory, proliferative, remodeling.
Inflammatory phase — duration?
Day 1 to 6 post-injury.
Cell recruitment — first responders?
Neutrophils arrive first, then monocytes/macrophages.
Neutrophil role?
Remove debris and prevent infection.
Macrophage role?
Regulate healing, produce growth factors, phagocytose debris.
Proliferative phase — key event?
Fibroblast activity, ECM deposition, angiogenesis.
Granulation tissue — components?
Fibroblasts, macrophages, endothelial cells.
Reepithelialization — process?
Migration and proliferation of keratinocytes.
Remodeling phase — main focus?
Collagen reorganization and tissue strengthening.
Type III collagen — role?
Early collagen in granulation tissue.
Type I collagen — role?
Mature collagen, provides tensile strength.
Wound contraction — cells involved?
Myofibroblasts pull wound edges together.
Primary intention — healing?
Edges approximated, minimal scarring.
Secondary intention — healing?
Wound heals from base with larger scar.
Tertiary intention — healing?
Delayed closure after initial open wound.
Factors affecting healing — systemic?
Nutrition, drugs, systemic diseases.
Factors affecting healing — local?
Oxygen, infection, radiation, neural supply.
Bone healing — initial step?
Haematoma formation at fracture site.
Bone healing — primary vs secondary?
Primary: direct, secondary: callus formation.
Nerve healing — process?
Wallerian degeneration, guided regeneration via neurotropism.
Testez vos connaissances avec un QCM de 12 questions sur Tissue Repair and Healing Processes.
1. Which cell type is primarily responsible for producing extracellular matrix components during the proliferative phase of wound healing?
2. What is the typical outcome of wound healing by primary intention?
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